Journal
NUTRITION AND PHYSICAL ACTIVITY IN AGING, OBESITY, AND CANCER
Volume 1271, Issue -, Pages 10-19Publisher
BLACKWELL SCIENCE PUBL
DOI: 10.1111/j.1749-6632.2012.06762.x
Keywords
SIRT1; cancer; subcellular localization
Funding
- Global Core Research Center (GCRC) from the National Research Foundation (NRF), Ministry of Education, Science and Technology (MEST), Republic of Korea [2012-0001184]
- World Class University (WCU) from the National Research Foundation (NRF), Ministry of Education, Science and Technology (MEST), Republic of Korea [R31-2012-000-10103-0]
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Silent mating type information regulation 1 (Sirtuin 1; SIRT1) has been reported to regulate various physiological events, such as aging and metabolism, via deacetylation of histone and nonhistone proteins. Notably, cumulative evidence supports the notion that SIRT1 has a Janus-faced role in tumorigenesis. SIRT1 contributes to anti-inflammation, genomic stability, and cancer cell death, and hence it has tumor-suppressor properties. On the other hand, SIRT1 can stimulate oncogenic signaling pathways and can create a tumor microenvironment favorable to growth and survival of cancer cells. Such dual functions of SIRT1 may be determined, at least in part, by its subcellular localization. Interestingly, SIRT1 displays differential localization in normal cells and cancer cells, which in turn may affect the substrate specificity for its deacetylase activity.
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