Journal
MYASTHENIA GRAVIS AND RELATED DISORDERS II
Volume 1275, Issue -, Pages 92-100Publisher
BLACKWELL SCIENCE PUBL
DOI: 10.1111/j.1749-6632.2012.06799.x
Keywords
thymectomy; thymitis; thymic atrophy; involution; morphometry; CD23
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Funding
- Myasthenia Gravis Foundation of America
- German Ministry of Education and Research (BMBF) [01DL12027]
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The MGTX trial is the first prospective, randomized clinical trial that aims to evaluate the impact of extended transsternal thymectomy on myasthenic symptoms, prednisone requirements, and quality of life in patients with non-thymomatous, anti-acetylcholine receptor autoantibody-positive myasthenia gravis (MG). Here, we give an overview of the rationale of thymectomy and the standardized macroscopic and histopathological work-up of thymectomy specimens as fixed in MGTX standard operating procedures, including the grading of thymic lymphofollicular hyperplasia and the morphometric strategy to assess thymic involution.
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