Journal
HEMATOPOIETIC STEM CELLS VIII
Volume 1266, Issue -, Pages 40-46Publisher
BLACKWELL SCIENCE PUBL
DOI: 10.1111/j.1749-6632.2012.06500.x
Keywords
hematopoietic stem cell division; divisional history; labeling technique; quiescence; active cycling
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Funding
- Japanese Society for the Promotion of Science for Research Abroad
- Swiss National Science Foundation [310030_131088/1]
- Promedica Foundation
- Marlis Geiser-Lemken Stiftung (Zurich, CH)
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Hematopoietic stem cell (HSC) division leads to self-renewal, differentiation, or death of HSCs, and adequate balance of this process results in sustained, lifelong, high-throughput hematopoiesis. Despite their contribution to hematopoietic cell production, the majority of cells within the HSC population are quiescent at any given time. Recent studies have tackled the questions of how often HSCs divide, how divisional history relates to repopulating potential, and how many HSCs contribute to hematopoiesis. Here, we summarize these recent findings on HSC turnover from different experimental systems and discuss hypothetical models for HSC cycling and maintenance in steady-state and upon hematopoietic challenge.
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