Journal
JOURNAL OF CLINICAL MICROBIOLOGY
Volume 44, Issue 3, Pages 1145-1149Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.44.3.1145-1149.2006
Keywords
-
Categories
Ask authors/readers for more resources
We evaluated a two-step algorithm for detecting toxigenic Clostridium difficile: an enzyme immunoassay for glutamate dehydrogenase antigen (Ag-EIA) and then, for antigen-positive specimens, a concurrent cell culture cytotoxicity neutralization assay (CCNA). Antigen-negative results were >= 99% predictive of CCNA negativity. Because the Ag-EIA reduced cell culture workload by approximate to 75 to 80% and two-step testing was complete in <= 3 days, we decided that this algorithm would be effective. Over 6 months, our laboratories' expenses were US$143,000 less than if CCNA alone had been performed on all 5,887 specimens.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available