Journal
JOURNAL OF PROTEOME RESEARCH
Volume 5, Issue 3, Pages 483-492Publisher
AMER CHEMICAL SOC
DOI: 10.1021/pr050244o
Keywords
Huntington's disease; metabolic profiling; NMR spectroscopy; pattern recognition; R6/2 mice
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Funding
- Wellcome Trust [051897, 066270, 060360] Funding Source: Medline
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The metabolic consequences of Huntington's disease in the R6/2 mouse model were investigated using NMR spectroscopy and pattern recognition to characterize selected brain regions, muscle, blood, and urine. Global increases in relative brain concentrations of osmolytes, creatine, glutamine, and lactate, and decreases in acetate and N-acetylaspartate were found together with striatal-specific lower concentrations of GABA and choline. Clear differentiation of R6/2 and wild-type mice was also obtained for urine and blood metabolite profiles that may have applicability for monitoring HD in human populations.
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