Journal
CRITICAL CONTRIBUTIONS OF THE ORBITOFRONTAL CORTEX TO BEHAVIOR
Volume 1239, Issue -, Pages 14-24Publisher
BLACKWELL SCIENCE PUBL
DOI: 10.1111/j.1749-6632.2011.06257.x
Keywords
orbitofrontal cortex; credit assignment; decision making; reversal learning; delay discounting
Funding
- Medical Research Council, UK
- Wellcome Trust
- MRC [G0902373, G0700399] Funding Source: UKRI
- Medical Research Council [G0700399, G0902373] Funding Source: researchfish
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The orbitofrontal cortex (OFC) has long been implicated in aspects of learning and adaptive decision making in changeable environments, but its precise role has remained elusive. One potential reason is that anatomical and functional distinctions within the OFC have often been overlooked. Here, we review findings centered largely on recent lesion studies in macaque monkeys from our laboratories that have investigated the causal role of the lateral and medial parts of the OFC (LOFC and MOFC) in choice behavior in uncertain, multioption environments. MOFC appears necessary for focusing attention on only the relevant decision variables to achieve a goal. By contrast, LOFC is required to allow rapid learning in changeable environments by enabling the credit for a particular outcome to be assigned to a specific choice.
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