Journal
ANIMAL MODELS: THEIR VALUE IN PREDICTING DRUG EFFICACY AND TOXICITY
Volume 1245, Issue -, Pages E1-E5Publisher
BLACKWELL SCIENCE PUBL
DOI: 10.1111/j.1749-6632.2011.06382.x
Keywords
systems pharmacology; network biology; personalized medicine
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Funding
- NIH [GM-54508, 071558]
- NIGMS [T32-GM062754]
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Systems pharmacology approaches can be used to identify and predict drug-induced adverse events. Disease-centered networks within the human interactome allow us to predict which drugs may produce a similar pathophysiology. Such predictions can be tested in animal models.
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