Journal
ANIMAL MODELS: THEIR VALUE IN PREDICTING DRUG EFFICACY AND TOXICITY
Volume 1245, Issue -, Pages 55-58Publisher
BLACKWELL SCIENCE PUBL
DOI: 10.1111/j.1749-6632.2011.06318.x
Keywords
diabetes; humanized mice; animal models; islets
Categories
Funding
- VA Research Service
- National Institutes of Health research [AI46629, DK72473, DK66636, DK68854]
- Beta Cell Biology Consortium [DK72473, DK89572]
- Vanderbilt Mouse Metabolic Phenotyping Center [DK59637]
- Vanderbilt Diabetes Research and Training Center [DK20593]
- University of Massachusetts Institutional Diabetes Endocrinology Research Center (DERC) [DK32520]
- Juvenile Diabetes Research Foundation International
- Helmsley Foundation
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The availability of immunodeficient mice engrafted with functional human immune systems and islets permits in vivo study of human diabetes without putting patients at risk.
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