Journal
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
Volume 84, Issue 3-4, Pages 431-441Publisher
NATL RESEARCH COUNCIL CANADA
DOI: 10.1139/Y06-002
Keywords
confocal microscopy; nuclear membranes; Na+-H exchanger; calcium channel; angiotensin II; endothelin-I
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The action of several peptides and drugs is thought to be primarily dependent on their interactions with specific cell surface G-protein-coupled receptors and ionic transporters Such as channels and exchangers. Recent development of 3-D confocal microscopy allowed several laboratories. including ours, to identify and study the localization of receptors, channels. and exchangers at the transcellular level of several cell types. Using this technique. we demonstrated in the nuclei of several types of cells the presence of Ca2+ channels is well as Na+-H+ exchanger and receptors Such as endothelin-1 and angiotensin 11 receptors. Stimulation of these nuclear membrane G-protein-coupled receptors induced an increase of nuclear Ca2+. Our results suggest that, similar to the plasma membrane. nuclear membranes possess channels, exchangers and receptors Such as those for endothelin-1 and angiotensin II. and that the nucleus seems to be a cell within a cell. This article will emphasize these findings.
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