Journal
TRANSFUSION CLINIQUE ET BIOLOGIQUE
Volume 13, Issue 1-2, Pages 167-168Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.tracli.2006.03.003
Keywords
Rhesus; Rh glycoproteins; Rhcg; gene targeting; komice; ammonium transport
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Ammonium excretion into urine is a major process essential to the regulation of acid-base homeostasis. We have shown that Rh-type proteins, including renal RhCG, belong to the Mep/Amt family of ammonium transporters and promote bi-directional ammonium transport upon heterologous expression in yeast. To study the physiological role of RhCG and to test a potential function in ammonium excretion, we have generated mice bearing an invalidation of the corresponding gene. (c) 2006 Elsevier SAS. All rights reserved.
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