Journal
BIOPHYSICAL JOURNAL
Volume 90, Issue 5, Pages 1594-1597Publisher
CELL PRESS
DOI: 10.1529/biophysj.105.074682
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Funding
- NIGMS NIH HHS [GM54215, R01 GM054215] Funding Source: Medline
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Manipulation of individual DNA molecules by optical tweezers has made it possible to tie these molecules into knots. After stretching the DNA molecules the knots become highly localized. In their recent study, Quake and co-authors investigated diffusion of such knots along stretched DNA molecules. We used these data to test the accuracy of a Brownian dynamics simulation of DNA bending motion. We simulated stretched DNA molecules with knots 31, 41, and 71, and determined their diffusion coefficients. Comparison of the simulated and experimental results shows that Brownian dynamics simulation is capable of predicting the rates of large-scale DNA rearrangements within a factor of 2.
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