Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 63, Issue 6, Pages 663-671Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-005-5425-4
Keywords
colorectal carcinoma; tumorigenesis; staging; matrix metalloproteinase; hedgehog; thymosin beta-4; stem cells; treatment
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Colorectal carcinoma (CRC) is a complicated and often fatal genetic disease. Fortunately, owing to rapid expansion of knowledge and technology development in oncology, much progress has been made regarding the diagnosis, understanding of the molecular genetics and malignant progression, as well as the novel regimens of CRC. In this review, we summarize the staging system, the most critical genetic and epigenetic alterations, the pleiotropic effects of MMP-7, the controversial roles of Hedgehog signaling, the intriguing involvement of thymosin beta-4, and the possible contribution of the putative colon (cancer) stem cells in CRC tumorigenesis. Current treatments as well as several potentially applicable therapeutic strategies for CRC are also discussed.
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