Journal
SKELETAL BIOLOGY AND MEDICINE
Volume 1192, Issue -, Pages 161-169Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2009.05249.x
Keywords
osteoporosis; bone metastases; lactation; estrogen deficiency; calcium-sensing receptor; parathyroid hormone-related protein
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Funding
- NATIONAL CANCER INSTITUTE [R01CA153702] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK077565, R01DK055501] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA153702] Funding Source: Medline
- NIDDK NIH HHS [R01 DK055501, R01 DK077565] Funding Source: Medline
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Mammalian reproduction requires that nursing mothers transfer large amounts of calcium to their offspring through milk. As a result, lactation is associated with dramatic alterations in bone and mineral metabolism, including reversible bone loss. One theme that has emerged from recent studies examining these adaptations is that the lactating breast actively participates in regulating bone and mineral metabolism. This review will detail our current knowledge of interactions between the breast, skeleton, and hypothalamus during lactation and will consider implications that this reproductive physiology has for the pathophysiology of osteoporosis and breast cancer.
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