Journal
MITOCHONDRIAL RESEARCH IN TRANSLATIONAL MEDICINE
Volume 1201, Issue -, Pages 50-57Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2010.05633.x
Keywords
bioenergetics; mitochondria; apoptosis; cell death; external pathway of NADH oxidation
Funding
- NIH [RO3DA021385, R01GM50284]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM050284] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R03DA021385] Funding Source: NIH RePORTER
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Mitochondrial bioenergetic function is a key to cell life and death. Cells need energy not only to support their vital functions but also to die gracefully. Execution of an apoptotic program includes energy-dependent steps, including kinase signaling, formation of the apoptosome, and effector caspase activation. Under conditions of bioenergetic collapse, cells are diverted toward necrotic demise. Mitochondrial outer membrane permeabilization (MOMP) is a decisive event in the execution of apoptosis. It is also causally linked to a decline in bioenergetic function via different mechanisms, not merely due to cytochrome c dispersion. MOMP-induced bioenergetic deficiency is usually irreversible and commits cells to die, even when caspases are inactive. Here, we discuss the mechanisms by which MOMP impacts bioenergetics in different cell death paradigms.
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