Journal
YEAR IN IMMUNOLOGY 2
Volume 1183, Issue -, Pages 13-24Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2009.05128.x
Keywords
thymic stromal lymphopoietin; TSLP; inflamation; asthma; atopic dermatitis; AD; cytokines
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Funding
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR047417] Funding Source: NIH RePORTER
- NIAID NIH HHS [N01 AI400030, N01AI40030] Funding Source: Medline
- NIAMS NIH HHS [R01 AR047417, R01 AR047417-09, AR-047417] Funding Source: Medline
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Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine expressed in skin, gut, lungs, and thymus. TSLP signals via a TSLP receptor (TSLPR), a heterodimer of the IL-7 receptor alpha chain and the TSLPR chain. The TSLPR chain is closely related to the common receptor gamma chain that is expressed on a wide range of cell types in the adaptive and innate immune system. TSLP exerts a profound influence on the polarization of dendritic cells to drive T helper (Th) 2 cytokine production. TSLP also directly promotes T-cell proliferation in response to T-cell receptor activation and Th2 cytokine production and supports B-cell expansion and differentiation. TSLP further amplifies Th2 cytokine production by mast cells and natural killer T cells. These properties confer on TSLP a critical role in driving Th2-mediated inflammation. This role is supported by the finding that TSLP expression is upregulated in keratinocytes of atopic dermatitis skin lesions and in bronchial epithelial cells in asthma.
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