Journal
YEAR IN NEUROLOGY 2
Volume 1184, Issue -, Pages E1-E20Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2010.05432.x
Keywords
-
Categories
Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [K08NS062890] Funding Source: NIH RePORTER
- NINDS NIH HHS [K08 NS062890-02, K08 NS062890] Funding Source: Medline
Ask authors/readers for more resources
The fruit fly, Drosophila melanogaster, has a long and rich history as an important model organism for biologists. In particular, study of the fruit fly has been essential to much of our fundamental understanding of the development and function of the nervous system. In recent years, studies using fruit flies have provided important insights into the pathogenesis of neurodegenerative and neuromuscular diseases. Flymodels of spinalmuscular atrophy, spinobulbar muscular atrophy,myotonic dystrophy, dystrophinopathies and other inherited neuromuscular diseases recapitulate many of the key pathologic features of the human disease. The ability to perform genetic screens holds promise for uncovering the molecular mechanisms of disease, and indeed, for identifying novel therapeutic targets. This review will summarize recent progress in developing fly models of neuromuscular diseases and will emphasize the contribution that Drosophila has made to our understanding of these diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available