Journal
OXIDATIVE/NITROSATIVE STRESS AND DISEASE
Volume 1203, Issue -, Pages 7-14Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2010.05554.x
Keywords
cytokines; chemokines; asbestos; inflammation; mesothelioma
Categories
Funding
- National Cancer Institute [P01CA114047, R01CA106567]
- National Institute of Environmental Health Sciences [T32ES007122]
- Lake Champlain Cancer Research Organization
- NATIONAL CANCER INSTITUTE [R01CA106567, P01CA114047] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [T32ES007122] Funding Source: NIH RePORTER
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Asbestos fibers cause chronic inflammation that may be critical to the development of malignant mesothelioma (MM). Two human MM cell lines (Hmeso, PPM Mill) were used in a SCID mouse xenograft model to assess time-dependent patterns of inflammation and tumor formation. After intraperitoneal (IP) injection of MM cells, mice were euthanized at 7, 14, and 30 days, and peritoneal lavage fluid (PLF) was examined for immune cell profiles and human and mouse cytokines. Increases in human MM-derived IL-6, IL-8, bFGF, and VEGF were observed in mice at 7 days postinjection of either MM line, and a striking neutrophilia was observed at all time points. Free-floating tumor spheroids developed in mice at 14 days, and both spheroids and adherent MM tumor masses occurred in all mice at 30 days. Results suggest that inflammation and cytokine production precede and may be critical to the development of MMs.
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