Journal
ADDICTION REVIEWS 2
Volume 1187, Issue -, Pages 35-75Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2009.05144.x
Keywords
nucleus accumbens; reinstatement; relapse; synaptic plasticity; pharmacotherapy; receptor
Categories
Funding
- NIDA NIH HHS [R01 DA015214, K01 DA030445, R01 DA022339, K02 DA018678, R01 DA22339, R01 DA15214, K02 DA18678] Funding Source: Medline
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA022339, K01DA030445, K02DA018678, R01DA015214] Funding Source: NIH RePORTER
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A growing body of evidence indicates that repeated exposure to cocaine leads to profound changes in glutamate transmission in limbic nuclei, particularly the nucleus accumbens. This review focuses on preclinical studies of cocaine-induced behavioral plasticity, including behavioral sensitization, self-administration, and the reinstatement of cocaine seeking. Behavioral, pharmacological, neurochemical, electrophysiological, biochemical, and molecular biological changes associated with cocaine-induced plasticity in glutamate systems are reviewed. The ultimate goal of these lines of research is to identify novel targets for the development of therapies for cocaine craving and addiction. Therefore, we also outline the progress and prospects of glutamate modulators for the treatment of cocaine addiction.
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