Journal
WOMEN'S HEALTH AND DISEASE
Volume 1205, Issue -, Pages 17-22Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1749-6632.2010.05659.x
Keywords
hematopoietic stem cells; umbilical cord blood; human leukocyte antigen disparity
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Umbilical cord blood (UCB) is a valuable alternative source of hematopoietic stem cells (HSCs). It has unique advantages of easy procurement, absence of risk to donors, low risk of transmitting infections, immediate availability, greater tolerance of human leukocyte antigen (H LA) disparity, and lower incidence of inducing severe graft-versus-host disease (GVHD). In the last several years, these features of UCB permit the field of UCB transplantation (UCBT) to move at a faster pace for both children and adults with malignancies and nonmalignancies. However, new strategies and novel developments are expected to improve engraftment and reconstitution, and to enable in titer transplantation for early therapy, as well as to allow the therapy for a wide spectrum of human diseases.
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