Journal
MICROBES AND INFECTION
Volume 8, Issue 3, Pages 866-872Publisher
ELSEVIER
DOI: 10.1016/j.micinf.2005.10.010
Keywords
Chlamydia pneumoniae; Chlamydia trachomatis; glycosaminoglycan; chondroitin sulfate A; heparin; pretreatment; inhibition; infectivity
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Glycosaminoglycans are known to participate in the attachment of several chlamydial strains. We studied the effect of heparin, enoxaparin, low-molecular-weight heparin, chondroitin sulfate A, and heparinase I on the infectivity of Chlamydia pneumoniae strain CWL029 and two Finnish isolates, Kajaani 7 and Parola, in an HL cell line which is epithelial in origin. Two Chlamydia trachomatis strains, L2 and E, were used for comparison. The infectivity of all C. pneumoniae strains and C. trachomatis serovar E was inhibited not only by heparin derivatives but also by chondroitin sulfate A and heparinase treatment. Treatment of host cells with heparin derivatives and heparinase was also inhibitory. Different chlamydial strains and species seem, however, to vary in their ability to use heparin in their attachment to host cells. (c) 2006 Elsevier SAS. All rights reserved.
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