Journal
ADDICTION REVIEWS 2
Volume 1187, Issue -, Pages 172-183Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2009.05142.x
Keywords
addiction; cocaine; maternal; dopamine; oxytocin; mother-child bonding; stress
Categories
Funding
- NCRR NIH HHS [MO1RR00188, M01 RR000188] Funding Source: Medline
- NICHD NIH HHS [K23 HD043097, K23 HD043097-05, K23 HD43097] Funding Source: Medline
- NIDA NIH HHS [DA022446-01A2, K05 DA020091, R01 DA006025, R01 DA-06025] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [K23HD043097] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000188] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA006025, P01DA022446, K05DA020091] Funding Source: NIH RePORTER
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Maternal cocaine addiction is a significant public health issue particularly affecting children, with high rates of reported abuse, neglect, and foster care placement. This review examines both preclinical and clinical evidence for how cocaine abuse may affect maternal care and infant development, exploring brain, behavioral, and neuroendocrine mechanisms. There is evidence that cocaine affects infant development both directly, via in utero exposure, and indirectly via alterations in maternal care. Two neural systems known to play an important role in both maternal care and cocaine addiction are the oxytocin and dopamine systems, mediating social and reward-related behaviors and stress reactivity. These same neural mechanisms may also be involved in the infant's development of vulnerability to addiction. Understanding the neuroendocrine pathways involved in maternal behavior and addiction may help facilitate earlier, more effective interventions to help substance-abusing mothers provide adequate care for their infant and perhaps prevent the intergenerational transmission of risk.
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