Journal
YEAR IN IMMUNOLOGY
Volume 1217, Issue -, Pages 77-82Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2010.05823.x
Keywords
vitamin D receptor; T cells; agonist selection; autoimmunity
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Funding
- NCCIH NIH HHS [R01 AT005378-01, R01 AT005378, AT005378] Funding Source: Medline
- NIDDK NIH HHS [DK070781, R01 DK070781, R01 DK070781-03] Funding Source: Medline
- NINDS NIH HHS [R01 NS067563-01A1, R01 NS067563] Funding Source: Medline
- National Center for Complementary & Integrative Health [R01AT005378] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK070781] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS067563] Funding Source: NIH RePORTER
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Vitamin D is an important regulator of immune function. T cells express the vitamin D receptor (VDR) and have been shown to be direct and indirect vitamin D targets. Why should T cells be responsive to vitamin D? The data suggest that expression of the VDR is required for the development of two cell types, NKT cells and CD8 alpha alpha T cells, which inhibit autoimmunity. In addition, effector T cell cytokine production is regulated by vitamin D. Available evidence suggests that NKT and CD8 alpha alpha T cells express the VDR as part of the selection process to protect against the generation of autoimmunity, particularly in the gut.
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