Journal
DISCOVERIES IN SPINAL CORD INJURY RESEARCH: FROM BENCH TO BEDSIDE
Volume 1198, Issue S1, Pages E12-E21Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2010.05565.x
Keywords
spinal cord injury; reflex conditioning; plasticity; H-reflex; learning and memory; locomotion; rehabilitation
Funding
- New York State Spinal Cord Injury Trust Fund
- National Institutes of Health [HD36020, NS061823, NS22189]
- Christopher Reeve Paralysis Foundation
- International Spinal Research Trust
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R01HD036020] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS061823, R01NS022189] Funding Source: NIH RePORTER
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Spinal reflex conditioning changes reflex size, induces spinal cord plasticity, and modifies locomotion. Appropriate reflex conditioning can improve walking in rats after spinal cord injury (SCI). Reflex conditioning offers a new therapeutic strategy for restoring function in people with SCI. This approach can address the specific deficits of individuals with SCI by targeting specific reflex pathways for increased or decreased responsiveness. In addition, once clinically significant regeneration can be achieved, reflex conditioning could provide a means of reeducating the newly (and probably imperfectly) reconnected spinal cord.
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