Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 61, Issue 3, Pages 232-244Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/61.3.232
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To investigate effects of aging on adhesion molecules (AMs), the present study assessed the expressions of aortic P-selectin and vascular adhesion molecule-1 (VCAM-1) in young (6-month-old) and old (24-month-old) Fischer 344 rats fed ad libitum (AL) or calorie-restricted diets. Results showed increased levels of aortic P-selectin and VCAM-1 in the old AL rats, causing excessive leukocyte infiltration as indicated by enhanced myeloperoxidase level. These elevations were parallel to increased oxidative stress including lipid peroxides during aging,, Then involvement of redox-sensitive transcription factor nuclear factor-kappa B was analyzed, and greater activation of nuclear factor-kappa B-inducing kinase (NIK)/I kappa B kinase (IKK)/Inhibitor of kappa B (I kappa B) pathway in aorta from old AL rats was found. Further, in cultured endothelial cells challenged by various oxidative stimuli, the induced redox imbalance triggered overexpression and promoter activities of P-selectin and VCAM-1. Our study documented that aortic upregulated AMs with age are closely related to activation of NIK/IKK/I kappa B/nuclear factor-kappa B pathway brought on by oxidative stress.
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