Journal
YEAR IN DIABETES AND OBESITY
Volume 1212, Issue -, Pages E37-E45Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2011.05984.x
Keywords
bariatric surgery; metabolic surgery; type 2 diabetes; gastric bypass; duodenal-jejunal bypass; glucose hemostasis
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Conventional bariatric operations, including Roux-en-Y gastric bypass (RYGB), laparoscopic adjustable gastric banding, and biliopancreatic diversion (BPD) appear to be a safe and effective treatment for many severely obese patients with type 2 diabetes mellitus (T2DM). These operations improve glucose homeostasis through a variety of mechanisms, however, not only due to reduced food intake and body weight. Research to elucidate the weight-independent antidiabetic mechanisms of gastrointestinal (GI) surgery and to clarify the molecular mechanisms responsible for the benefits of GI surgery on glucose homeostasis is a compelling research objective. We review the existing knowledge regarding the clinical outcomes and of the mechanisms of GI surgery to treat T2DM.
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