Journal
INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE
Volume 1170, Issue -, Pages 623-628Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1749-6632.2009.03877.x
Keywords
ZIP8; ZIP14; DMT1; transporters; paracellular transport; olfactory; nasal; solute carriers
Funding
- National Institutes of Health [T42/OH008432-01, ES06096]
- NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH [T42OH008432] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES006096] Funding Source: NIH RePORTER
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Substances that enter the nasal cavity can access the bloodstream or central nervous system by processes including receptor cell uptake, transneuronal transport, and paracellular transport. Until recently, the molecular mechanisms by which agents move from the nasal cavity have not been described. Although the full complement of transporter proteins found in the nasal cavity has certainly not yet been identified, several recent observations have advanced this field substantially. We summarize here a representative sample of transporter proteins found in olfactory mucosa and/or nasal respiratory mucosa and the substrates that they transport into the brain and/or bloodstream.
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