4.8 Article

Intramolecular cyclopropanation of unsaturated terminal aziridines

Journal

ORGANIC LETTERS
Volume 8, Issue 5, Pages 995-998

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol060101n

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Regio- and stereoselective deprotonation of bishomoallylic terminal N-Bus (Bus = tert-butylsulfonyl)-protected aziridines generate aziridinyl anions that undergo diastereoselective intramolecular cyclopropanation giving trans-2-aminobicyclo[3.1.0]hexanes in good to excellent yields.

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