Journal
HYPOXIA AND CONSEQUENCES FROM MOLECULE TO MALADY
Volume 1177, Issue -, Pages 66-73Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2009.05039.x
Keywords
mitochondria; ROS; glycolysis; Warburg effect; ATP; NADPH; TCA cycle; glutamine
Funding
- NIH [ROICA123067-03]
- Consortium of Independent Lung Health Organizations
- NATIONAL CANCER INSTITUTE [R01CA123067] Funding Source: NIH RePORTER
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Historically, it has been assumed that glycolytic metabolism, not mitochondrial metabolism, is essential for tumor cell proliferation. However, most tumor cells have functional mitochondria, and recent studies suggest that the citric acid cycle (TCA) cycle intermediates are precursors for synthesis of nucleotides, lipids, and amino acids. Here we review the accumulating evidence that mitochondrial metabolism plays an essential role in tumor cell proliferation.
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