Journal
NEUROIMMUNOMODULATION: FROM FUNDAMENTAL BIOLOGY TO THERAPY
Volume 1153, Issue -, Pages 57-64Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2008.03974.x
Keywords
neuronal survival; IL-2; IL-4; IL-6; trophic factors; development
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Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Conselho Nacional de Desenvolvimento Cientifico c Tecnologico
- Programa de Apoio a Nucleos de Excelencia-Ministerio de Ciencia e Tecnologia
- Fundacao de Amparo a Pesquisa do estado do Rio de Janeiro
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One of the central issues in neuroscience today is the study of the mechanisms of neuronal survival. Since the discovery of nerve growth factor (almost 60 years ago), many groups have clearly demonstrated the central role of neurotrophins on the regulation of neuronal cell survival during developmental stages as well as during adult life. However, neurotrophins are not alone in regulating neuronal survival, and many groups have demonstrated the effect of different cytokines on this phenomenon. In this brief review we will address the effect of interleukins (IL), particularly IL-2, IL-6, and IL-4, on the survival of neuronal cells.
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