Journal
RELAXIN AND RELATED PEPTIDES: FIFTH INTERNATIONAL CONFERENCE
Volume 1160, Issue -, Pages 219-220Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2008.03785.x
Keywords
bone; INSL3; osteoblast; osteoporosis; RXFP2
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Funding
- NICHD NIH HHS [R01 HD037067, R01 HD037067-10] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD037067] Funding Source: NIH RePORTER
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We have recently demonstrated that the disruption of the INSL3 hormonal system, as observed in humans with mutations in the RXFP2 gene and in Rxfp2-deficient mice, might affect the equilibrium of the osteoblast-osteoclast system, resulting in an imbalance between bone formation and bone resorption that may result in reduced bone mass. In the present study we have better characterized the in vitro effects of INSL3 on human osteoblasts. Stimulation of human primary osteoblasts with INSL3 at serial concentrations (1 pM, 1 nM, and 1 mu M) induced a dose-dependent increase in osteoblast proliferation and expression of specific ostcoblast genes.
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