Journal
CONTEMPORARY CHALLENGES IN AUTOIMMUNITY
Volume 1173, Issue -, Pages 501-508Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1749-6632.2009.04625.x
Keywords
autoantibody; gene; interleukin-10; polymorphism; rheumatoid arthritis; severity
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Funding
- Ministry of Health of the Czech Republic [NR7812-3/2004]
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Interleukin-10 (IL-10) is a major anti-inflammatory cytokine that plays a crucial role in the regulation of the immune system. Allelic polymorphisms in the IL-10 gene promoter may contribute to the regulation of autoantibody production. To examine the association between both individuals IL-10 single nucleotide polymorphisms and the production of autoantibodies and the radiographic progression of rheumatoid arthritis (RA), a total of 144 RA patients were recruited into the study. We found significant differences in genotype distribution of the -1082G/A polymorphism between IgG, IgA, and IgM rheumatoid factor(RF)-positive/negative RA patients. We also found significant differences in allelic frequencies of the -3575T/A, -819C/T, and -592A/C polymorphisms between anticyclic citrullinated peptide (anti-CCP)-positive/negative RA patients. The haplotype TGAATA was found to be less frequent within anti-CCP-positive RA patients. Results obtained in this study provide evidence of an association between polymorphisms in IL-10 gene promoter and the production of autoantibodies in RA patients.
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