Journal
YEAR IN EVOLUTIONARY BIOLOGY 2009
Volume 1168, Issue -, Pages 23-51Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2009.04880.x
Keywords
evolution; cancer; mathematical modeling
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As Theodosius Dobzhansky famously noted in 1973, Nothing in biology makes sense except in the light of evolution, and cancer is no exception to this rule. Our understanding of cancer initiation, progression, treatment, and resistance has advanced considerably by regarding cancer as the product of evolutionary processes. Here we review the literature of mathematical models of cancer evolution and provide a synthesis and discussion of the field.
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