Journal
YEAR IN NEUROLOGY 2
Volume 1184, Issue -, Pages 188-195Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2009.05118.x
Keywords
alpha-synuclein; disease progression; Lewy bodies; Parkinson's disease
Categories
Ask authors/readers for more resources
To identify the progression of pathology over the entire course of Parkinson's disease, we longitudinally followed a clinical cohort to autopsy and identified three clinicopathological phenotypes that progress at different rates. Typical Parkinson's disease has an initial rapid loss of midbrain dopamine neurons with a slow progression of Lewy body infiltration into the brain (over decades). Dementia intervenes late when Lewy bodies invade the neocortex. Older onset patients (> 70 years old) dement earlier and have much shorter disease durations. Paradoxically, they have far more alpha-synuclein-containing Lewy bodies throughout the brain, and many also have additional age-related plaque pathology. In contrast, dementia with Lewy bodies has the shortest disease course, with substantive amounts of Lewy bodies and Alzheimer-type pathologies infiltrating the brain. These data suggest that two age-related factors influence pathological progression in Parkinson's disease-the age at symptom onset and the degree and type of age-related Alzheimer-type pathology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available