Journal
FEBS LETTERS
Volume 580, Issue 6, Pages 1625-1630Publisher
WILEY
DOI: 10.1016/j.febslet.2006.02.008
Keywords
indole-diterpenes; paspaline; paxilline; FAD-dependent monooxygenase; prenyl transferase; Penicillium paxilli
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Paspaline belongs to a large, structurally and functionally diverse group of indole-diterpenes synthesized by filamentous fungi. However, the identity of the gene products required for the biosynthesis of paspaline, a key intermediate for the synthesis of paxilline and other indole-diterpenes, is not known. Transfer of constructs containing different pax gene combinations into a paxilline negative deletion derivative of Penicillium paxilli demonstrated that just four proteins, PaxG, a geranylgeranyl diphosphate synthase, PaxM, a FAD-dependent monooxygenase, PaxB, a putative membrane protein, and PaxC, a prenyl transferase, are required for the biosynthesis of paspaline. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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