Journal
TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY
Volume 1163, Issue -, Pages 60-74Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1749-6632.2008.03624.x
Keywords
C. elegans; FaRP; Locusta migratoria; locusts; nematodes; neuropeptide F/Y; peptide precursor processing; peptidomics; Schistocerca gregaria
Funding
- Research Foundation of the K.U.Leuven [GOA/2005/09]
- Fund for Scientific Research (FWO)-Flanders (Belgium) [1.5.137.06, G.0580.06, G.0434.07]
- EC
- SJH
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Both the long and short neuropeptides F (NPF) represent important families of invertebrate neuropeptides that have been implicated in the regulation of reproduction and feeding behavior. In the present study, two short NPFs (SNRSPS(L)/(I)R(L)/(I)RFamide and SpS(L)/(I)R(L)/(I)RFamide) were de novo sequenced by mass spectrometry in two major pest insects, the desert locust Schistocerca gregaria and the African migratory locust Locusta migratoria. They are two of the most widespread peptides in the locust neuroendocrine system. A peptide that was previously reported to accelerate egg development in S. gregaria is shown to represent a truncated form of long NPF. This peptide is most likely derived by a novel processing mechanism involving cleavage at RY. In addition, an NPF peptide from the nematode Caenorhabditis elegans was isolated and sequenced by tandem mass spectrometry.
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