Journal
CANCER VACCINES
Volume 1174, Issue -, Pages 24-32Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2009.04999.x
Keywords
dendritic cell; vaccine; immunology
Categories
Funding
- NCI NIH HHS [R01 CA078846-04, P01 CA084512-060005, R01 CA078846-02, P01 CA084512-01A10003, R01 CA078846, P01 CA084512-05A29002, R01 CA078846-10, R01 CA085540-02, R01 CA078846-09, P01 CA084512-07, P01 CA084512-07S1, P01 CA084512-05A29004, R01 CA078846-07, P01 CA084512, P01 CA084512-070005, R01 CA078846-01A1, P01 CA084512-069002, P01 CA084512-079002, R01 CA085540-01A1, R01 CA078846-05, R01-CA84512, P01 CA084512-020003, R01 CA085540-03, R01-CA078846, R01 CA078846-08, R01 CA078846-06, P01 CA084512-05A2, P01 CA084512-069004, P01 CA084512-030003, P01 CA084512-06, P01 CA084512-05A20005, P01 CA084512-079004, P01 CA084512-040003, R01 CA078846-03, R01 CA085540, R01 CA085540-04] Funding Source: Medline
- NIAID NIH HHS [U19 AI057234-05S10012, U19 AI057234-06, U19 AI057234-06S15042, U19 AI057234-06S1, U19 AI057234-05S10013, U19-AI057234, U19 AI057234-06S2, U19 AI057234-010006, U19 AI057234-010005, U19 AI057234-05S19003, U19 AI057234-06S3, U19 AI057234-02, U19 AI057234, U19 AI057234-05, U19 AI057234-05S1, U19 AI057234-04, U19 AI057234-01, U19 AI057234-010004, U19 AI057234-03] Funding Source: Medline
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Dendritic cells (DCs) orchestrate a repertoire of immune responses that endow resistance to infection and tolerance to self. DC plasticity and subsets are prominent determinants of the quality of elicited immune responses. Different DC subsets display different receptors and surface molecules and express different sets of cytokines/chemokines, all of which lead to distinct immunological outcomes. Recent findings on human DC subsets and their functional specialization have provided insights for the design of novel human vaccines.
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