Journal
MOLECULAR STRUCTURE AND FUNCTION OF THE TIGHT JUNCTION: FROM BASIC MECHANISMS TO CLINICAL MANIFESTATIONS
Volume 1165, Issue -, Pages 121-125Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1749-6632.2009.04024.x
Keywords
MDCK; epithelia; cyclin D1; tight junction; ZO-2; MAGUK
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Funding
- Mexican Council for Science and Technology (CONA-CYT) [45691-Q, 41273-A, 50414, 166727, 159492]
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ZO-2 is an adaptor protein of the tight junction that belongs to the MAGUK protein family. ZO-2 is a dual localization protein that in sparse cultures is present at the cell borders and the nuclei, whereas in confluent cultures it is concentrated at the cell boundaries. Here we have studied whether ZO-2 is able to regulate the expression of cyclin D I (CD1) and cell proliferation. We have demonstrated that ZO-2 negatively regulates CD1 transcription by interacting with c-Myc at an E box present in CD1 promoter. We have further found that ZO-2 transfection into epithelial MDCK cells triggers a diminished expression of CD I protein and decreases the rate of cell proliferation in a wound-healing assay.
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