Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 10, Pages 3693-3697Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0511189103
Keywords
animal model; gene mutation; psychiatric disorder; schizophrenia
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Funding
- NIMH NIH HHS [MH67068, R01 MH067068] Funding Source: Medline
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Disrupted-in-Schizophrenia (DISC1) is a leading candidate schizophrenia susceptibility gene. Here, we describe a deletion variant in mDisc1 specific to the 129S6/SvEv strain that introduces a termination codon at exon 7, abolishes production of the full-length protein, and impairs working memory performance when transferred to the C57BL/6J genetic background. Our findings provide insights into how DISC1 variation contributes to schizophrenia susceptibility in humans and the behavioral divergence between 129S6/SvEv and C57BL/6J mouse strains and have implications for modeling psychiatric diseases in mice.
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