Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 533, Issue 1-3, Pages 171-181Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2005.12.066
Keywords
tachykinin; substance P; neurokinin A; asthma; chronic obstructive pulmonary disease; airway inflammation
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The tachykinins Substance P and neurokinin A are present in human airways, in sensory nerves and immune cells. Tachykinins can be recovered from the airways after inhalation of ozone, cigarette smoke or allergen. They interact in the airways with tachykinin NK1, NK2 and NK3 receptors to cause bronchoconstriction, plasma protein extravasation, and mucus secretion and to attract and activate immune cells. In preclinical studies they have been implicated in the pathophysiology of asthma and chronic obstructive pulmonary disease, including allergen- and cigarette smoke induced airway inflammation and bronchial hyperresponsiveness and mucus secretion. Dual NK1/NK2 or triple NK1/NK2/NK3 tachykinin receptor antagonists offer therapeutic potential in airway diseases Such as asthma and chronic obstructive pulmonary disease. (c) 2005 Elsevier B.V. All rights reserved.
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