Journal
STEROID ENZYMES AND CANCER
Volume 1155, Issue -, Pages 316-323Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2008.03679.x
Keywords
Parkinson's disease (PD); high performance liquid chromatography (HPLC); striatum; brain stem; cerebellum; cortex; hippocampus; 6-OHDA; monoamines
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Funding
- Ateneo di Palermo research funding [ORPA068JJ5]
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6-Hydroxydopamine (6-OHDA) is a neurotoxic compound commonly used to induce dopamine (DA) depletion in the nigrostriatal system, mimicking Parkinson's disease (PD) in animals. The aim of the present study was to evaluate the 7-day effect of unilateral nigral lesion on rat brain monoamine neurochemistry. Five brain regions were examined: the brain stem, cerebellum, hippocampus, striatum, and cortex. 6-OHDA-unilateral lesion dramatically modified DA, serotonin (5-HT) and their metabolites contents in both sides of the different brain nuclei. Furthermore, unilateral 6-OHDA lesion reduced DA and 5-HT contents and produced a robust inversion of their turnover in the nonlesioned side compared to sham-operated rats. These data suggest that 6-OHDA unilateral nigral lesion produces bilateral monoamine level modifications, and this piece of evidence should be taken into account when one interprets data from animal models of unilateral PD.
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