Journal
CANCER LETTERS
Volume 234, Issue 1, Pages 51-61Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2005.05.051
Keywords
multidrug-resistance; transport; bile acids; morphine; allosteric stimulation
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MRPs are membrane proteins transporting organic anions at the expense of ATP hydrolysis. MRP2 is known to be a major transporter of organic anions from the liver into bile. We discuss recent results showing allosteric control of human but not rat MRP2. MRP3 has been considered a major player in bile salt metabolism, but our recent results with Mrp3 KO mice do not support this. Instead, we have found a role for MRP3 in the cellular export of drug-glucuronide conjugates. We discuss problems in extrapolating results obtained for murine MRPs. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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