Journal
JOURNAL OF CONTROLLED RELEASE
Volume 111, Issue 1-2, Pages 1-18Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2005.10.031
Keywords
gastroretentive forms; Helicobacter pylori; adhesive systems; specific targeting
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The challenge to develop efficient gastroretentive dosage forms began about 20 years ago, following the discovery of Helicobacter pylori by Warren and Marshall. In order to understand the real difficulty of increasing the gastric residence time of a dosage form, we have first summarized the important physiologic parameters, which act upon the gastric residence time. Afterwards, we have reviewed the different drug delivery systems designed until now, i.e. high-density, intragastric floating, expandable, superporous hydrogel, mucoadhesive and magnetic systems. Finally, we have focused on gastroretentive dosage forms especially designed against H. pylori, including specific targeting systems against this bacterium. (c) 2005 Elsevier B.V. All rights reserved.
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