Journal
INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE
Volume 1170, Issue -, Pages 664-673Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2009.04373.x
Keywords
plasticity; adult stem cells; neurotransmitter; neurogenesis; neural activity
Funding
- NIH
- McKnight Scholar
- NARSAD
- Rett Syndrome Research Foundation
- Muscular Dystrophy Association
- Packard Center for ALS Research at Johns Hopkins
- Sloan, March of Dimes
- Adelson Medical Research foundation
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R01HD069184] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [P20MH084018] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS048271, R01NS047344] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG024984] Funding Source: NIH RePORTER
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The adult mammalian brain continuously generates new neurons in the olfactory bulb and hippocampus throughout life. Adult neurogenesis, a highly dynamic process, has been shown to be exquisitely modulated by neuronal circuit activity at different stages, from proliferation of adult neural progenitors, to differentiation, maturation, integration, and survival of newborn neurons in the adult brain. Strategic activity-dependent addition of new neurons into the existing neuronal circuitry represents a prominent form of structural plasticity and may contribute to specific brain functions, such as learning, memory, and mood modulation. Here we review extrinsic mechanisms through which adult neurogenesis is regulated by environmental cues, physiological learning-related stimuli, and neuronal activities.
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