Metal-free catalytic nucleophilic substitution of propargylic alcohols

Organic acids such as PTS efficiently catalyze direct nucleophilic substitutions of the hydroxy groups of propargylic alcohols with a large variety of carbon- and heteroatom-centered nucleophiles. Reactions can be conducted under mild conditions and in air without the need for dried solvents. Reactions on multigram scales are also possible. (c) Wiley-VCH Verlag GmbH & Co.