Journal
MITOCHONDRIA AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISORDERS
Volume 1147, Issue -, Pages 171-179Publisher
WILEY-BLACKWELL
DOI: 10.1196/annals.1427.020
Keywords
mitochondria; crista; electron microscopy; electron tomography; membrane dynamics; membrane topology; apoptosis; cardiolipin; Mgm1; OPA1; t-Bid; adenine nucleotide translocator; ATP synthase; dominant optic atrophy; oxidative stress; reactive oxygen species
Funding
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR001219] Funding Source: NIH RePORTER
- NCRR NIH HHS [P41 RR001219, P41 RR001219-27, RR01219] Funding Source: Medline
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Mitochondria display considerable structural diversity particularly in terms of the folding of the energy-transducing inner membrane. The hypothesis is forwarded that the topology of the mitochondrial inner membrane is not random but rather is a regulated cell parameter. Its effects on internal diffusion of metabolites and soluble proteins can influence such mitochondrial processes as ATP production and protein release during apoptosis. Progress toward understanding the factors that control mitochondrial inner-membrane curvature and dynamics (fusion and fission) is summarized, with a focus on remodeling events associated with apoptosis and oxidative stress.
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