Journal
LYMPHATIC CONTINUUM REVISITED
Volume 1131, Issue -, Pages 13-36Publisher
WILEY-BLACKWELL
DOI: 10.1196/annals.1413.002
Keywords
lymph flow; NIR optical imaging; fluorescence; indocyanine green
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Funding
- NCI NIH HHS [R01 CA112679, R01 CA112679-14] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA112679] Funding Source: NIH RePORTER
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In this review, we provide a comprehensive summary of noninvasive imaging modalities used clinically for the diagnosis of lymphatic diseases, new imaging agents for assessing lymphatic architecture and cancer status of lymph nodes, and emerging near-infrared (NIR) fluorescent optical imaging technologies and agents for functional lymphatic imaging. Given the promise of NIR optical imaging, we provide example results of functional. lymphatic imaging in mice, swine, and humans, showing the ability of this technology to quantify lymph velocity and frequencies of propulsion resulting from the contractility of lymphatic structures.
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