Journal
DRUG ADDICTION: RESEARCH FRONTIERS AND TREATMENT ADVANCES
Volume 1139, Issue -, Pages 20-26Publisher
WILEY-BLACKWELL
DOI: 10.1196/annals.1432.054
Keywords
dopamine receptor; gene polymorphism; opioid dependence; cold-pressor test; male
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Funding
- Chinese University of Hong Kong [204-1108]
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Heroin users exhibit abnormal pain sensitivity called opioid-induced hyperalgesia that may weaken their determination to abstain. The dopamine receptor D4 gene (DRD4) is associated with heroin dependence; one of its polymorphisms is a C/T variation 521 by upstream to the gene (-521C/T). We investigated whether this polymorphism was related to opioid dependence through modulation of cold-pain responses. We recruited 84 heroin-dependent Chinese male subjects and 168 healthy male Chinese controls. Genotyping was performed by PCR-RFLP A significantly higher T allele frequency was observed in the heroin group (P = 0.041). Of the cohort recruited, 43 current heroin users and 66 controls were further subjected to a cold-pressor test (CPT) to determine their pain threshold and tolerance. TT controls demonstrated a significantly lower pain threshold than did their CC/CT counterparts (P = 0.022) and TT opioid users (P = 0.006). Moreover, CC/CT controls had a significantly higher pain tolerance than TT controls (P = 0.042) and CC/CT opioid users (P = 0.010). The data suggest that DRD4 -521C/T plays an important role in opioid dependence through modulating cold-pain responses. TT individuals might have a higher tendency to use opioids because they experience pain less strongly after chronic opioid use.
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