Journal
IMMUNOLOGY OF DIABETES V: FROM BENCH TO BEDSIDE
Volume 1150, Issue -, Pages 190-196Publisher
WILEY-BLACKWELL
DOI: 10.1196/annals.1447.055
Keywords
type 1 diabetes; prevention; immunomodulation; clinical trials
Funding
- NIDDK NIH HHS [U01 DK061041-06, U01 DK061041] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [U01DK061041] Funding Source: NIH RePORTER
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This paper reviews worldwide efforts to interdict the type 1 diabetes (T1D) disease process, during the stage of evolution of the disease prior to the time of disease onset. The goal of intervention before disease onset is to arrest immune destruction and thus prevent or delay clinical disease. In this regard, there have been several large-scale multicenter randomized controlled clinical trials designed to prevent T1D. These have tested nicotinamide, parenteral insulin, oral insulin, nasal insulin, and the elimination of cow's milk from infant feeding.
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