Journal
VACCINE
Volume 24, Issue 12, Pages 2200-2207Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2005.11.002
Keywords
dengue; vaccines; combined; DNA vaccines
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We developed a dengue tetravalent DNA vaccine consisting of plasmids expressing premembrane and envelope genes of each of four serotypes of dengue viruses. BALB/c mice immunized twice with the tetravalent vaccine at a dose of 100 p,g (25 mu g for each serotype) using a needle-free jet injector developed neutralizing antibodies against all serotypes. There was no interference among the four components included in this combination vaccine. Tetravalent vaccine-immunized mice showed anamnestic neutralizing antibody responses following challenge with each dengue serotype: responses to challenges from serotypes different to those used for neutralization tests were also induced. (c) 2005 Elsevier Ltd. All rights reserved.
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