Journal
JOURNAL OF NEUROSCIENCE
Volume 26, Issue 11, Pages 2951-2955Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.5554-05.2006
Keywords
visual deprivation; ocular dominance; AMPA receptor; NMDA receptor; GABA(A) receptor; synaptic plasticity
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Funding
- NEI NIH HHS [EY13818] Funding Source: Medline
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Brief monocular deprivation (<= 3 d) induces a rapid shift in the ocular dominance of binocular neurons in the juvenile rodent visual cortex but is ineffective in adults. Here, we report that persistent, rapid, juvenile-like ocular dominance plasticity can be reactivated in adult rodent visual cortex when monocular deprivation is preceded by visual deprivation. Ocular dominance shifts in visually deprived adults are caused by a rapid depression of the response to stimulation of the deprived eye, previously only reported in juveniles, and a simultaneous potentiation of the response to stimulation of the nondeprived eye. The enhanced ocular dominance plasticity induced by visual deprivation persists for days, even if binocular vision precedes monocular deprivation. Visual deprivation also induces a significant decrease in the level of GABA(A) receptors relative to AMPA receptors and a return to the juvenile form of NMDA receptors in the visual cortex, two molecular changes that we propose enable the persistent reactivation of rapid ocular dominance plasticity.
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